What type of hepatotoxicity is associated with iron poisoning?
Zone 1 (periportal) necrosis. Toxicity is related to oxidative damage due to high concentrations of iron and oxygen in the periportal region.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Tenenbein M. Hepatotoxicity in acute iron poisoning. J Toxicol Clin Toxicol 2001;39(7):721-6. doi: 10.1081/clt-100108513.