In the case series examining the use of fomepizole as an adjunct in the treatment of acetaminophen overdose, what is the proposed mechanism for how fomepizole would reduce hepatotoxicity in patients with acetaminophen toxicity?
Fomepizole is a CYP2E1 inhibitor, which can prevent acetaminophen conversion to the hepatotoxic metabolite NAPQI.
Rampon, G.L., Wartman, H., Osmon, S., & Scalzo, A.J. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications, 2019; 4(1): 1 – 4.
Submitted by: Molly Stott, PharmD and Dawn Sollee, PharmD, DABAT