Squarticles are a lipid nanosystem that was developed for delivery of anti-alopecia drug delivery to hair follicles. Experiments to characterize Squarticles in drug poisoning have also begun. In comparison to Intralipid, which is made from egg phospholipids, soybean oil and glycerol what is the primary lipid source in Squarticles?
Squalene – which is derived most commonly from shark liver oil.
Chen CH, Huang TH, Elzoghby AO, Wang PW, Chang CW, Fang JY. Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification [published correction appears in Int J Nanomedicine. 2019 Sep 11;14:7363]. Int J Nanomedicine. 2017;12:8071-8083. Published 2017 Nov 1. doi:10.2147/IJN.S143370
This question was submitted by Jillian Theobald, MD, PhD