Question - What characterizes acute liver injury caused by the drug nitrofurantoin?
Answer - The cited article notes “The acute liver injury caused by nitrofurantoin usually presents within a few days to weeks after the initiation of therapy. One report noted nitrofurantoin-induced acute liver injury after a single dose of the drug. The pattern of liver injury usually is hepatocellular with or without jaundice and typically includes symptoms of fever, rash, and laboratory signs of elevated liver enzymes and eosinophilia”. (Sakaan SA et al. Nitrofurantoin-induced hepatotoxicity: A rare yet serious complication. 2014 South Med J 107(2):107-113)