A 55 year old male was recently started on a new medication for diabetes management. He presents to the Emergency Department with angioedema. What is the likely culprit?
Dipeptidyl Peptidase-4 Inhibitor. Dipeptidyl Peptidase-4 Inhibitors affect the degradation of the vasoactive kinins bradykinin and substance P, both of which can cause angioedema.
Scott SI et al. Dipeptidyl Peptidase-4 Inhibitor Induced Angioedema–An Overlooked Adverse Drug Reaction. Curr Diabetes Rev 2018; 14(4): 327-333/. doi: 10.2174/1573399813666170214113856