Chronic isoniazid toxicity can cause peripheral neuropathy that is preventable with concurrent administration of pyridoxine. What manifestation of chronic toxicity is not prevented by concurrent pyridoxine administration?
Hepatotoxicity. Some studies have shown a mortality benefit in using corticosteroids and N-acetylcysteine early in the course of liver injury. In rare instances, the hepatotoxicity from INH can be very severe prompting the need for an emergency liver transplant.
Badrinath M, John S. Isoniazid Toxicity. [Updated 2021 Jul 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK531488/
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