Question: What are the most common adverse effects of the topically applied (applied directly to the eye) aminoglycosides tobramycin and gentamicin?
Answer: Superficial punctate lesions on the cornea are the most common findings in patients receiving topical aminoglycosides. Corneal ulceration and conjunctival psuedomemebranes may occur but are rare. (Fraunfelfder FW. Corneal toxicity from topical ocular and systemic medications. 2006 Cornea 25:1133-1138)