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June 21, 2017

Question of the Day – Wednesday June 21, 2017

Question: Can buprenorphine be used as an effective modality for the treatment of neonatal abstinence syndrome?

Answer: A recently published article described a double blind, double dummy clinical trial of 63 infants who were exposed to opioids in utero. The authors of this study reported “The median duration of treatment was significantly shorter with buprenorphine than with morphine (15 days vs. 28 days), as was the median length of hospital stay (21 days vs. 33 days) (P<0.001 for both comparisons). Adjunctive phenobarbital was administered in 5 of 33 infants (15%) in the buprenorphine group and in 7 of 30 infants (23%) in the morphine group (P=0.36). Rates of adverse events were similar in the two groups.” (Kraft WK et al. Buprenorphine for the treatment of the neonatal abstinence syndrome. 2017 NEJM 376(24):2341-2348)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • AACT Fundamentals of Toxicology Research Seminar
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • BRIDGES Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
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