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The American Academy of Clinical Toxicology
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April 19, 2017

Question of the Day – Wednesday April 19, 2017

Question: Hereditary angioedema may be clinically confused with severe drug related reactions in some circumstances. What is hereditary angioedema and what is the cause for hereditary angioedema?

Answer: The cited reference notes: “Hereditary angioedema is a disabling and potentially fatal condition characterized by recurrent episodes of swelling without urticaria or pruritus. The condition is caused by deficiency  (type I) or dysfunction (type II) of the C1 inhibitor protein, Patients have insufficient C1 inhibitor function to prevent bradykinin production by the contact system, leading to episodes if increased capillary hyper-permeability and swelling. These episodes manifest clinically as angioedema attacks.” (Longhurst H et al. Prevention of hereditary angioedema attacks with a subcutaneous C1 inhibitor. 2017 NEJM 376(12): 1131-1140)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • After the Fact CE
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