Question: The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. The development of which human cancer has been liked to exposure to this chemical?
Answer: The cited reference points out that “The aromatic amine 4-aminobiphenyl is present in cigarette smoke and is excreted in the urine in forms that lead to DNA adduct formation……….this combination of increased mutagenic DNA adduct formation by 4-ABP and increased [bladder] cell proliferation leads to a significant incidence of bladder tumors, with cigarette smoking being the major cause of bladder cancer in the United States. (Cohen SM and Arnold LL. Chemical carcinogenesis. 2011 Tox Sci 120(S1): S76-S92)
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