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July 20, 2017

Question of the Day – Thursday July 20, 2017

Question: Vitamin D intoxication is an uncommon problem for pediatric aged patients. What is the clinical presentation of children suffering from hypervitaminosis D?

Answer: The cited reference reports: “Children with vitamin D intoxication present with symptoms of hypercalcemia, such as poor appetite, weight loss, abdominal pain, vomiting, constipation, polyuria, and polydipsia, and in severe cases, life-threatening dehydration. Because the complaints of hypercalcemia are nonspecific, symptoms can be present for prolonged periods before a child worsens and comes to medical attention. In some cases, the concentration of calcium in the glomerular filtrate may exceed its solubility, resulting in calcium precipitation in the renal tubules and nephrocalcinosis. This complication occurs in approximately 25% of patients with vitamin D intoxication, whereas in some pediatric series, vitamin D intoxication accounts for about 10% of all cases of nephrocalcinosis. Dehydration, decreased glomerular filtration rate, and nephrocalcinosis may all compromise renal function resulting in renal tubular acidosis and insufficiency. Metastatic vascular calcifications have also been reported.” (Vogiatzi MG et al. Vitamin D supplementation and risk of toxicity in pediatrics: A review of current literature. 2014 J Clin Endocrinol Metab 99: 1132–1141)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • General Information Post-Conference
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