Question: Which GABA’ergic drugs are not reversed by the drug flumazenil?
Answer: The cited reference notes “Flumazenil has a very rapid onset of action after parenteral administration, and competitively antagonizes the sedating effects of a wide range of benzodiazepines such as midazolam, diazepam and lorazepam at the GABAA receptor. …….It does not reverse the effects of other GABA’ergic sedative/hypnotics such as barbiturates, inhalational anesthetics, propofol or ethanol nor does it reverse the effects of opioids.” (Silvotti M. Flumazenil, naloxone and the “coma cocktail”. 2015 Br J Clin Pharm 81(3):428-236)
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