Question: What is malignant hyperthermia?
Answer: The cited reference reports “Malignant hyperthermia is the term used to describe a clinical crisis induced by halogenated inhalational anesthetics and/or succinylcholine. These trigger agents cause a dysregulation of intracellular calcium of the striated muscle cell leading to life threatening hypermetabolism and muscle rigidity…..There are a few reports on lethal malignant hyperthermia like reactions unrelated to anesthesia. The susceptibility to malignant hyperthermia is a paradigm for a pharmacogenetic disorder requiring for its clinical manifestation the cooperative effects of a genetic predisposition plus an external triggering factor. (Broman M et. al. Malignant hyperthermia, a Scandinavian update. 2015 Acta Anesth Scan 59:951-961)