Question: What are the contraindications and relative contraindications to intranasal naloxone administration?
Answer: The cited reference notes “Contraindications to intranasal administration can include nasal septal abnormalities, nasal trauma, epistaxis, excessive nasal mucus, and intranasal damage caused by the use of substances such as cocaine.” These authors also note “Relative contraindications to intranasal naloxone use include severe hypotension and the recent use of vasoconstrictors, which may prevent adequate absorption.” (Robinson A and Wermeling DP. Intranasal naloxone administration for the treatment of opioid overdose. 2014 Am J Health-Sys Pharm 71:2129-2135)
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