Question- What is the metabolic fate of THC following oral ingestion?
Answer- The cited article notes following oral ingestion, “Peak plasma levels of THC are typically reached in 1 to 3 hours. THC subsequently undergoes rapid hepatic first pass metabolism into 11-hydroxy-delta-THC which is then further oxidized to the inactive THC-COOH, 8-hydroxy-delta-THC and other conjugated metabolites.” (Vo KT et al. Cannabis intoxication case series: The dangers of edibles containing tetrahydrocannabinol. 2018 Ann Emerg Med 71(3):306-313)