Question Of The Day

In a recent study, what was one of the differences of F(AB’)-2 compared to FAB? a. Increased immediate allergic reactions in the F(AB’)-2 group b. Higher rate of type III hypersensitivity reactions in the F(AB’)-2 group compared to FAB group. c. Increased persistent, recurrent or…

Which fat substitute has been a suggested treatment for organochlorine toxicity?   Olestra Redgrave TG, Wallace P, Jandacek RJ, Tso P. Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. J Nutr Biochem. 2005 Jun;16(6):383-4. doi: 10.1016/j.jnutbio.2004.12.014. PMID: 15936651….

What effect does N-acetylcysteine have on measurement of Prothrombin Time and what is a proposed mechanism?   N-acetylcysteine has been shown in healthy volunteer subjects to interfere with PT measurement by decreasing the activity of factors II, VII, IX, and X. The mechanism is unclear,…

This biochemical marker has been theorized to be a predictor of delayed neurologic sequalae after carbon monoxide poisoning.   Netrin-1. Netrin-1 has been previously investigated as a predictive biomarker of neurologic sequalae following both hemorrhagic and ischemic stroke. Kokulu K et al. sought to examine…

Aleurites Moluccana, often referred to as “Nuez de la India”, has been purported to be an effective weight loss supplement. Unfortunately, these non-toxic candlenuts have been mistaken for this which has resulted in toxicity?   Due to similar appearances, candlenuts have been inadvertently substituted with…

In a recent randomized study in patients with anticholinergic toxicity, fewer patients that received physostigmine compared to lorazepam had this effect?   Delirium. According to a recent paper by Wang et al., fewer patients receiving physostigmine had delirium compared to lorazepam. Wang GS et al….

Use of this drug, for its antioxidant effects, may decrease the toxicity secondary to aluminum phosphide?   N-Acetylcysteine. Tehrani et al. in a prospective, randomized, open-label trial evaluated the effects of NAC on patients with acute aluminum phosphide toxicity. In the NAC group, there was…

Unlike research suggestive of a ‘ceiling effect’ for respiratory depression after higher doses of buprenorphine in adults, pediatric exposures to buprenorphine result in respiratory depression not insignificantly. What is one proposed mechanism for this?   P-Glycoprotein (P-gp). P-gp plays an important role against toxicity by…

What are some potential causes of a false positive ethylene glycol result by enzymatic assay? 1. Diabetic Ketoacidosis 2. Elevated Lactate and LDH 3. Propylene glycol   Carlos Martinez, MD, Hanna Lubbos, MD, Leslie I. Rose, MD, Charles Swartz, MD, and Fredrick Kayne, PhD (1998)…

Two patients present to the hospital with nausea, vomiting and diarrhea that started 12 hours after ingestion of a meal they prepared with foraged mushrooms. What qualititative test can be done to determine if the mushrooms contain amatoxin?   Wieland-Meixner test. The Meixner test has…