Bexarotene (Targetrin) is a third generation retinoid indicated for the treatment of cutaneous T cell lymphoma. This side effect occurs in 40-70% of patients treated with this drug?
Bexarotene causes rapid and profound thyrotropin suppression and central hypothyroidism in 40-70% of patients. Normal recovery of thyroid function occurs within weeks after drug discontinuation. (Burch HB. Drug Effects on the Thyroid. NEJM 2019; 381: 749-761)
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