Question - What are the clinical symptoms associated with the development of sinusoidal obstruction syndrome (formerly known as veno-occlusive disease) and what is the relevant histology?
Answer - The cited article notes that “Symptoms of abdominal pain, increase in liver size, and weight gain, followed by jaundice, appear 1 to 3 weeks after exposure and may progress rapidly to hepatic failure.” These authors also point out “Liver histologic studies show dilatation of sinusoids and extravasation of red cells, with hepatocyte necrosis in central areas (zone 3).” (Hoofnagle JH and Bjornsson ES. Drug-induced liver injury- Types and phenotypes. 2019 NEJM 381:264-273)
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