Question - What is the so-called “differentiation syndrome”?
Answer- The cited article notes “Differentiation syndrome (DS), formerly known as retinoic acid syndrome, is a relatively common and potentially severe (and potentially life threatening) complication seen in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and/or arsenic trioxide. The full-blown syndrome consists of unexplained fever, weight gain, dyspnea with pulmonary infiltrates, pleuropericardial effusion, hypotension, and renal failure.” (Sanz MA and Montesinos P. How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia. 2014 Blood 123:2777-2782)
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