Question - What is the difference in rates of adverse events when the Wyeth Crotalidae polyvalent antivenom is compared with the currently recommended Crotalidae polyvalent immune Fab antivenom (CroFab)?
Answer- According to the cited article, the Wyeth Crotalidae polyvalent antivenom “was associated with a high rate of acute adverse events, 18-33%, including anaphylactoid and anaphylactic reactions”. In comparison the prevalence of Crotalidae polyvalent immune Fab antivenom (CroFab) adverse events was reported to be 2-7%. (Kleinschmidt K et al. Acute adverse events associated with the administration of Crotalidae polyvalent immune Fab antivenom within the North American Snakebite Registry. 2018 Clin Tox 56(11):1115-1120)
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