Question - What drug has recently been approved as therapy for severe sinusoidal obstruction syndrome (formerly known as veno-occlusive disease)?
Answer - The cited article reports “Defibrotide, an antithrombotic agent, has recently been approved as therapy for severe sinusoidal obstruction syndrome with organ failure, but its use is controversial.” Hoofnagle JH and Bjornsson ES. Drug-induced liver injury- Types and phenotypes. 2019 NEJM 381:264-273)
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