Question of the Day – Friday August 2, 2019

Question – What hepatic complication, characterized by pruritus and jaundice accompanied by moderate-to-marked elevations in alkaline phosphatase levels is noted to be caused by amoxicillin–clavulanate, cephalosporins, terbinafine, azathioprine, and temozolomide.

 

 

Answer – Cholestatic hepatitis is noted to be caused by amoxicillin–clavulanate, cephalosporins, terbinafine, azathioprine, and temozolomide. (Hoofnagle JH and Bjornsson ES. Drug induced liver injury- Types and phenotypes.2019 NEJM 381:264-273)