Question of the Day – Friday August 30, 2019

Question – What is the most important dose-limiting toxicity associated with the use of deoxycholate amphotericin B?

 

 

Answer – Nephrotoxicity is noted as the most important dose-limiting toxicity associated with the use of deoxycholate amphotericin B. The cited article notes “Amphotericin B-induced nephrotoxicity, although reversible, has been associated with increased morbidity, mortality and hemodialysis as well as protracted hospital stays and higher costs.” (Bes DF et al. Deoxycholate amphotericin B and nephrotoxicity in the pediatric setting.2014 Pediatr Infect Dis J 33:e198-e206)