To what familiar drug is orphenadrine most closely related?
Diphenhydramine. Orphenadrine is ortho-methyl diphenhydramine (adding one methyl group to one of the benzene rings
Dhaliwal N, Roberts DM. Clinical outcomes associated with orphenadrine deliberate self-poisoning: a retrospective poisons centre study. Clin Toxicol 2024 (online ahead of print). DOI: 10.1080/15563650.2024.2323678
Contributed by Michael Mullins, MD