What is the mechanism of clarithromycin interaction with digoxin?
Clarithromycin inhibits p-glycoprotein and is associated with a 70% increase in digoxin serum concentrations after 7 days of combination therapy.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Tanaka H, et al. Effect of clarithromycin on steady-state digoxin concentrations. Ann Pharmacother 2003;37(2):178-81. doi: 10.1177/106002800303700202.
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