What is the mechanism of action of Levosimendan?
“Levosimendan is a calcium sensitizer and its mechanism differs from other inotropes. Levosimendan enhances cardiac contraction by improving the use of available cytosolic calcium, rather than by flooding the cell with excessive calcium”
Varpula T, Rapola J, Sallisalmi M, Kurola J. Treatment of serious calcium channel blocker overdose with levosimendan, a calcium sensitizer. Anesth Analg. 2009 Mar;108(3):790-2. doi: 10.1213/ane.0b013e3181931737. PMID: 19224785.
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