Question - With regard to the treatment of long acting anticoagulant rodenticide (LAAR) poisoning, the addition of what drug to the treatment regimen has been advocated in order to increase hepatic elimination via increased microsomal activity?
Answer- The cited article notes: “In addition to standard therapies, phenobarbital has been used in the treatment of LAAR poisoning in an effort to increase hepatic elimination via increased microsomal activity. Some reports indicate that phenobarbital has successfully decreased the half-lives of chlorophacinone and warfarin. In cases of human LAAR poisoning, reported doses of phenobarbital included 200 mg daily and 30 mg 4 times a day.” (King N and Tran MH. Long acting anticoagulant rodenticide (Superwarfarin) poisoning: A review of its historical development, epidemiology and clinical management. 2015 Transfusion Med 29:250-258)