Question - Activation of the aryl hydrocarbon receptor (AhR) by xenobiotics has been linked to the development of what dermal toxicity?
Answer - The activation of the aryl hydrocarbon receptor (AhR) by xenobiotics has been linked to the development chloracne. (Forrester AR et al. Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenz0-p-dioxin (TCDD) is dependent on aryll hydrocarbon receptor activation ands is not reproduced by aryl hydrocarbon receptor knock down. 2014 J Derm Sci 73:10-22)
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