Question of the Day – Friday February 9, 2018

Question- What is the elimination half-life of methadone?

Answer- The cited reference reported: “The median elimination half life of methadone in healthy subjects was 33-46 hours depending in the method used to calculate this parameter.” (Wolff K et al. (1997). “The pharmacokinetics of methadone in healthy subjects and opiate users”. Br J Clin Pharmacol 44:325-334)