Question: The triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia characterize the hemolytic uremic syndrome (HUS). This typically occurs following a GI infection with which toxin producing pathogen?
Answer: The cited article notes “Typically, it occurs after a gastrointestinal infection with a Shiga toxin (Stx) producing pathogen. This diarrhea- or Stx-associated HUS (D1HUS or Stx-HUS) accounts for 90% of cases. Currently, there are no direct treatments and limited prevention strategies. Most patients recover from the acute illness, but there is a 1% to 4% mortality and one-third of patients are left with long-term medical problems.” (Keir LS. Shiga toxin associated hemolytic uremic syndrome. 2015 Hematol Oncol Clin N Am 29:525-539)