AACT Section Webinar: Acute & Intensive Care (AIC)

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Title:
Acetaminophen, Adducts and Antidotes: Too much of a good thing? And what does the future hold?

Description:
Acetaminophen overdose remains one of the leading causes of acute liver failure, yet few technical, clinically relevant advances have been made in diagnosis and management of the critically ill, acetaminophen poisoned patient. Are acetaminophen-protein adducts truly the future? Is too much NAC, too much of a good thing? This session will review emerging evidence on acetaminophen-protein adducts as early biomarkers of hepatotoxicity and examine their potential role in improving patient assessment and clinical decision-making. The presentation will also explore data suggesting that while N-acetylcysteine (NAC) remains the cornerstone antidote for acetaminophen poisoning, prolonged or delayed administration may influence liver regeneration after injury.

Presenters:
Laura James, MD
Director, Translational Research Institute; Associate Vice Chancellor for Clinical and Translational Research; Professor of Pediatrics
Translational Research Institute

Hartmut Jaeschke, PhD, ATS, FAASLD
University Distinguished Professor, Pharmacology, Toxicology & Therapeutics
Kansas University Medical Center

Moderator:
Sukhshant Atti, MD
Associate Professor
University of Alabama at Birmingham

American Academy of Clinical Toxicology
Acetaminophen, Adducts and Antidotes: Too much of a good thing? And what does the future hold?
September 1, 2026
Online

Continuing Education Language

Joint Accreditation Statement
In support of improving patient care, this activity has been planned and implemented by Amedco LLC and American Academy of Clinical Toxicology. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education(ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Amedco Joint Accreditation Provider Number: 4008163

Professions in scope for this activity are listed below.

Physicians
Amedco LLC designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits for physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Pharmacists & Pharmacy Technicians
Amedco LLC designates this activity for a maximum of 1.0 knowledge-based CPE contact hours.

NOTE to Pharmacists:
The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 45 days of your participation in the activity to meet the deadline for submission to CPE Monitor. Credits are generally reported during the first week of each month for those who claimed during the month prior.