AACT Staff

When evaluating a patient with potential myocarditis secondary to an Immune Checkpoint Inhibitor, what criteria should be used to aid in the diagnosis and treatment? Bonaca’s criteria. Bonaca MP et al. Myocarditis in the Setting of Cancer Therapeutics. Circulation 2019; 140(2):80-91. https://doi.org/10.1161/CIRCULATIONAHA.118.034497

In a patient with acetaminophen-induced hepatotoxicity, what may the thromboelastography (TEG) show? In a recent retrospective review of nine patients who were admitted for acetaminophen toxicity to a transplant center, TEG showed a decreased rate of fibrin formation and cross linking as well as decreased…

Immune Checkpoint Inhibitors result in a variety of adverse events. What is the newly emerging overlap syndrome that is associated with a high mortality? Myocarditis, myositis and myasthenia gravis. In a recent letter to the editor, Lipe DM et al. describe several reported cases of…

What does this mathematical equation describe: [(All current cases at one point in time)/(Total Study Population)] Prevalence. DiSalvo P and Su MK. Biostatistics and Epidemiology for the Toxicologist: Incidence and Prevalence. JMT 2022; 18: 56-57.  

When thinking about biostatistics and epidemiology, what does this definition describe? “The occurrence of new cases of disease or injury in a population over a specific period of time” Incidence. DiSalvo P and Su MK recently pubished a review discussing accurate epidemiologic terminology. Incidence and…

What is the very potent oxidant responsible for acetaminophen’s toxicity? Peroxynitrite. Protein adducts in mitochondria trigger superoxide formation which eventually leads to phosphorylation of c-jun N-terminal kinase (JNK) which triggers further impairment of the electron transport chain which leads to mitochondrial superoxide formation through complex…

Which halogenated hydrocarbon can lead to a reversable, subacute neurotoxicity and is now being marketed as a new form of “poppers”? Ethyl chloride has been reported to cause a reversable, subacute neurotoxicity that is imaging negative. Prior reports document ataxia, cerebellar dysfunction, drowsiness. Death has…

What was the effect of the water supply change in Flint, MI on pediatric blood lead levels? A retrospective analysis analyzed blood lead levels (BLL) in Flint children aged 5 years and younger over three periods: Period 1 from 25 April 2006 to 15 October…

Exposure to low levels of this metal in drinking water has been correlated with increased rates of cerebrovascular disease, diabetes mellitus, and kidney disease? A standardized mortality ratio analysis was conducted in a contiguous six-county area of southeastern Michigan to investigate the relationship between moderate…

What is Desalkylflurazepam? Desalkylflurazepam is a pharmacologically active benzodiazepine and metabolite of Flurazepam. It is also used in the manufacturing of midazolam, and can be found in trace amounts in patients treated with midazolam iatrogenically. Vogt S, Kempf J, Buttler J, Auwärter V, Weinmann W….