Question of the Day – Wednesday, March 27, 2024

In a retrospective review of data from the National Poison Data System, the safety of physostigmine in pediatric patients was assessed. What was the median age of the patients who received physostigmine? The median age of the groups that received physostigmine was 15 years. Huber…

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Question of the Day – Monday, March 25, 2024

The American Geriatric Society published its most recent Beers Criteria in 2023. What are Beers Criteria and in what circumstances can these criteria be applied? The AGS’ Beers Criteria identify potentially inappropriate medication (PIM) use in older adults. The criteria are intended to apply to…

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Question of the Day – Friday, March 22, 2024

In a retrospective, cross-sectional study performed in an urban hospital in Minneapolis, MN, what was the greatest risk factor for patients having physical restraints applied? Drug and alcohol intoxication was associated with the highest odds ratio of having physical restraints (adjusted odds ratio [aOR] 8.29;…

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Question of the Day – Thursday, March 21, 2024

Historical QOD 3/2/2009: What findings predominate in renal biopsies of patients with lithium toxicity? Chronic tubulointerstitial nephropathy (CTIN), cortical and medullary tubular cysts and dilatation, and focal segmental and global glomerulosclerosis.  Image: Severe lithium-associated chronic tubulointerstitial nephropathy (CTIN) with diffuse interstitial fibrosis and tubular atrophy…

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Question of the Day – Tuesday, March 19, 2024

What is the mechanism for colchicine induced cardiotoxicity? Although widely used in gout and pericarditis, colchicine can cause cardiotoxicity when taken in overdose due to its narrow therapeutic window. Though not well understood, high levels of colchicine may induce microtubule depolymerization, thus inhibiting contractility and…

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Question of the Day – Monday, March 18, 2024

In a small retrospective case control study of patients with delusions of parasitosis, exposure to what medications was associated with the delusions? Patients with delusions of parasitosis were more commonly exposed to attention deficit disorder medications, selective serotonin reuptake inhibitors, opioids, and gabapentin, along with…

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Question of the Day – Friday, March 15, 2024

A study of 6101 adult cancer survivors showed the prevalence of active substance use disorder (SUD) was 3.83% (SE, 0.32%). In what types of cancer was the highest prevalence of SUD found? SUD was most prevalent in survivors of head and neck cancer (9.36% [SE,…

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Question of the Day – Thursday, March 14, 2024

Historical QOD 2/27/2009: Cold allodynia (dysesthesia when touching cold water or cold objects) is characteristic of ingestion of fish containing what toxins? Ciguatoxins. Note that cold allodynia is often incorrectly termed “temperature reversal.” Isbister GK, Kiernan MC. Neurotoxic marine poisoning. Lancet Neurol. 2005 Apr;4(4):219-28. doi:…

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Question of the Day – Wednesday, March 13, 2024

In a study of patients who underwent spinal surgery, what medication was given during surgery that resulted in a 20% reduction of opiate use postoperatively compared to placebo? N-acetylcysteine was given at a dose of 150 mg/kg and resulted in a 20% decrease in opiate…

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Question of the Day – Tuesday, March 12, 2024

In a small study conducted in a Veterans Affairs hospital in Indianapolis, what was the most common way prescribers identified potential drug-drug interactions? 52% were detected by an alert in the electronic health record, 43% were identified independently by the prescriber themselves, and 5% were…

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