Question of the Day – Wednesday, November 2, 2022

Which class of pesticides can produce the symptom shown in this photo? Carbamates. Olive green urine has been reported following carbofuran ingestion. The discoloration is thought to be due to phenolic metabolites. Viswanathan S, John A. Common poison, uncommon urine. Nephrology (Carlton). 2011 Aug;16(6):617-8. doi:…

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Question of the Day – Tuesday, November 1, 2022

Which monoterpene found in pennyroyal oil is responsible for it’s pulmonary and hepatotoxic effects? Pulegone Anderson IB, Mullen WH, Meeker JE, Khojasteh-BakhtSC, Oishi S, Nelson SD, Blanc PD. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern…

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Question of the Day – Monday, October 31, 2022

In the retrospective survey conducted by Fuentes et. al of the women who admitted to attempting a self-managed abortion, what percentage used herbal products? 43.10% Fuentes, L., Baum, S., Keefe-Oates, B. et al. Texas women’s decisions and experiences regarding self-managed abortion. BMC Women’s Health 20,…

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Question of the Day – Friday, October 28, 2022

In the descriptive retrospective survey conducted by Ciganda and Laborde, what was the most commonly used herbal as an abortifacient? Ruda Carmen Ciganda M.D. & Amalia Laborde M.D. (2003) Herbal Infusions Used for Induced Abortion, Journal of Toxicology: Clinical Toxicology, 41:3, 235-239, DOI: 10.1081/ CLT-120021104…

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Question of the Day – Thursday, October 27, 2022

According to a recent prospective study, how effective is a single, large dose of intramuscular naloxone in reversing opioid toxicity in adult patients in the outpatient setting? In the cited reference, a single 1.6 mg IM dose of naloxone was effective in initially reversing respiratory…

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Question of the Day – Wednesday, October 26, 2022

In the out-of-hospital setting, larger intramuscular doses of naloxone may be used because the IM route is more rapid and reliable. What is the frequency of severe agitation following administration of a single 1.6 mg IM naloxone dose in patients with opioid toxicity in the…

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Question of the Day – Tuesday, October 25, 2022

According to a recent systematic review of ethylene glycol poisoning, mortality was unlikely to occur if the glycolate concentration was under what value? Various studies have demonstrated that the anion gap is a good correlate for the glycolate concentration in the setting of ethylene glycol…

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Question of the Day – Monday, October 24, 2022

In the out-of-hospital setting, larger intramuscular doses of naloxone may be used because the IM route is more rapid and reliable. What is the frequency of severe agitation following administration of a single 1.6 mg IM naloxone dose in patients with opioid toxicity in the…

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Question of the Day – Friday, October 21, 2022

In a recent multicenter prospective study of children who presented to the emergency department with opioid intoxication, what characteristics predicted severe outcome (ICU admission or in-hospital death)? Fentanyl exposure and age > 10 years. Cohen N, Mathew M, Davis A, et al. Predictors of severe…

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Question of the Day – Thursday, October 20, 2022

What is the most common laboratory interference in patients with thiocyanate toxicity? Pseudohyperchloremia, especially as measured by ion selective electrodes. In the cited reference, chloride values were repeatedly elevated (113–148 mmol/L) or not reported due to instrument error flags, including “above measurement range” (reported in…

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