Question: What is so-called “NSAID colopathy”?
Answer: The cited reference notes “The term NSAID colopathy has been used for non-specific colonic injury seen at colonoscopy, ranging from erosions to ulcers, with or without strictures, which have been seen with NSAID (including low-dose aspirin) use. It does not have the protean manifestations of small bowel injury. The resolution of the findings with cessation of NSAID exposure has supported their etiological role, but proof with repeat challenge has not been clearly demonstrated in most cases. Diaphragm disease of the colon may be considered diagnostic for NSAID-induced colon injury, although only a relatively small number of cases have been reported. Diclofenac-extended release formulations have been frequently implicated, supporting a role for high local drug concentrations due to its enterohepatic recirculation.” (Scheiman JM. NSAID-induced gastrointestinal injury: A focused update for clinicians. 2016 J Clin Gastroenterol 50:5–10)