Question of the Day – Monday January 29, 2018

Question- Oseltamivir is a neuraminidase inhibitor for influenza A and B virus and is frequently prescribed during epidemics of influenza. What is the potential interaction between oseltamivir and warfarin?

Answer- While the interactions between oseltamivir and warfarin have not been fully elucidated, several case reports suggest that patients taking both of these drugs simultaneously may manifest prolongation of the INR as well as a reversible coagulopathy. (Shah SP et al. Review of potential drug interaction between oseltamivir and warfarin and why it is important for emergency medicine physicians. 2017 Am J Emerg Med 35:1207.e3-1207.e4)